Proarrhythmic potential of halofantrine, terfenadine and clofilium in a modified in vivo model of torsade de pointes
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چکیده
منابع مشابه
Sotalol-induced torsade de pointes.
A case of sotalol-induced polymorphous ventricular tachycardia (torsade de pointes) is presented. The patient had moderately prolonged Q-T interval before medication with sotalol with further prolongation after application of this drug. Electrophysiological study during rechallenge with sotalol demonstrated a uniform ventricular tachycardia with a somewhat polymorphous onset; whether or not thi...
متن کاملDrug-induced torsade de pointes.
A73-year-old man with mild coronary artery disease and a dilated cardiomyopathy presented to the emergency room with a hemodynamically stable wide-QRS tachycardia. His 12-lead ECG revealed episodes of ventriculoatrial block, and a diagnosis of ventricular tachycardia (VT) was made (Figure 1). Intravenous procainamide restored sinus rhythm. Tachycardia recurred, and a second bolus of intravenous...
متن کاملMoxifloxacin-induced torsade de pointes
Torsade de pointes (TdP) is increasingly recognized as a complication of drug therapy. The most common cause of drug-induced QT prolongation is inhibition of the rapidly activating component of the delayed potassium current (IKr). Moxifloxacin, a widely used fluoroquinolone, is a weak IKr inhibitor and has been associated with QT prolongation. We report a case of marked QT prolongation (618 ms)...
متن کاملAmiodarone-associated proarrhythmic effects. A review with special reference to torsade de pointes tachycardia.
PURPOSE To assess the incidence of amiodarone-mediated aggravation of ventricular tachyarrhythmias or the development of new arrhythmias, such as torsade de pointes, in patients with cardiac disease. DATA SOURCES AND STUDY SELECTION A MEDLINE literature search was done to identify articles published during the last 20 years that presented data on amiodarone-associated proarrhythmic events. Th...
متن کاملa contrastive study of rhetorical functions of citation in iranian and international elt scopus journals
writing an academic article requires the researchers to provide support for their works by learning how to cite the works of others. various studies regarding the analysis of citation in m.a theses have been done, while little work has been done on comparison of citations among elt scopus journal articles, and so the dearth of research in this area demands for further investigation into citatio...
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ژورنال
عنوان ژورنال: British Journal of Pharmacology
سال: 2002
ISSN: 0007-1188
DOI: 10.1038/sj.bjp.0704550